In this Explorer’s Way episode, Dennis McKenna lays down a pretty narrow definition of what a true psychedelic is; and he’s not shy about it.
For Dennis, these are specific 5‑HT2A active compounds like psilocybin, LSD, DMT, mescaline and a few close cousins, not every wellness trend that slaps ‘psychedelic’ on the label.
And he’s earned that right to be picky. Dennis is one of the leading ethnopharmacologists of psilocybin‑containing mushrooms and Amazonian plant medicines, with decades of work on how these molecules behave in both the brain and in culture.
When that guy says our definitions matter, it’s worth listening.
Tune in to hear why he thinks the word ‘psychedelic’ should stay sharp, and what gets lost when we dilute it.. check out Pt. 1 The Reality Hallucination, and get ready for Pt. 2 dropping soon!

