Imperatorin is a linear furanocoumarin, characterized by a fused furan and coumarin ring system. This bioactive compound is commonly found in plants like Angelica dahurica, Citrus species, Peucedanum ostruthium, and Ammi majus.
Among its possible health benefits:
· Anticancer
· Antiinflammatory
· Anticoagulant
· Neuroprotective
· Cardiotoxicity Protection
One interesting study demonstrated that imperatorin-loaded lipid microspheres significantly enhanced bioavailability and inhibited proliferation of MDA-MB-231 cancer cells. A more recent study examined imperatorin’s protective effects against doxorubicin-induced cardiotoxicity, a common side effect of the chemotherapy drug doxorubicin. Imperatorin was found to reduce cardiac damage by inhibiting the NLRP3 inflammasome pathway, which plays a role in inflammation and cell death. Through this mechanism, imperatorin could potentially serve as a cardioprotective agent, reducing doxorubicin’s harmful effects on the heart without compromising its cancer-fighting properties.
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Imperatorin- Important Bioactive From Plants!
