Part 3 of my Explorer’s Way podcast conversation with Dennis McKenna dives into the genuinely strange frontier of psychedelic science…where our current models of the brain, consciousness, and plant chemistry start to break down.
In this episode, Dennis talks about why attempts to create “non‑psychedelic psychedelics” may be missing the point, and why he thinks the transformative power of these medicines can’t be separated from the experiences themselves.
We explore the cutting‑edge work around ibogaine, including research he believes will force neuroscience to revise some of its core assumptions, and then venture into the uncanny territory of a mysterious bolete mushroom that reliably makes people see “little people” for days at a time.
This final chapter in the Explorer’s Way mini‑series is less about tidy answers and more about the questions that arise when the data (and the entities) don’t fit our usual categories, inviting us to reconsider what we mean by medicine, reality, and the edge of what’s knowable.
In case you missed the first parts of these Explorer’s Way Episodes, please check them out on The Ethnobotanical Explorer’s channel on You Tube: P1. The Reality Hallucination & Pt. 2 Beyond The Trip…Responsibility & Reciprocity.

