Post Series: Biochemical Pathways & Bioactives
I wanted to do this post series as I think it is very powerful to understand the biochemical pathways that our various bioactives, dietary supplements and nutraceuticals are affecting. We often talk about clinical studies, but I think less often is there debate and discussion on biochemical mechanisms… This week, let’s start with the Methylation Pathway!
Ever wondered how your body responds to the environment—turns genes on and off in response to diet, stress, and toxins? This is due to a biochemical process called methylation. It is essential for life and impacts everything from DNA expression to detoxification and mood regulation.
💫This also explains the importance of B Vitamins!!
What is Methylation?
Methylation is the process of adding a methyl group (CH₃) to molecules like DNA, proteins, and neurotransmitters. This tiny chemical tag acts as a switch, controlling how genes are expressed—without changing the DNA itself.
Why is Methylation Important?
✔ Gene Regulation: Turns genes on or off, influencing how we age, adapt to stress, and fight diseases.
✔ Detoxification: Supports the liver in neutralizing toxins and heavy metals.
✔ Neurotransmitter Balance: Helps produce serotonin, dopamine, and melatonin, affecting mood, sleep, and focus.
✔ Energy Production: Plays a role in mitochondrial function and ATP synthesis.
✔ Immune Function: Regulates inflammation and supports white blood cell activity.
Cofactors that Power Methylation
For methylation to work properly, the body needs key B vitamins and nutrients, including:
✅ Folate (B9) & B12 – Essential for converting homocysteine into methionine, a building block for DNA repair.
✅ Choline & Betaine – Support alternative methylation pathways.
✅ Magnesium & Zinc – Help enzymes function in methylation reactions.
✅ SAMe (S-Adenosyl Methionine) – The body’s primary methyl donor, fueling hundreds of biochemical processes.
When Methylation Goes Wrong
Impaired methylation can lead to:
🚨 Increased risk of cardiovascular disease (high homocysteine levels)
🚨 Poor detoxification and hormone imbalances
🚨 Brain fog, anxiety, and mental health issues
🚨 Compromised immune function
How to Support Healthy Methylation:
🥦 Eat folate-rich foods: Leafy greens, liver, legumes, beets, and eggs
💊 Consider bioavailable methylated B vitamins (if needed)
🚶♂️ Reduce stress & support detox pathways through exercise and hydration
🥑 Balance your diet with healthy fats, amino acids, and minerals
Methylation isn’t just a biochemical process—it’s your body’s master control system, shaping how you respond to your environment and maintain long-term health. Keep it running smoothly, and your genes will thank you! 💙✨
#Methylation #Epigenetics #Folate #B12 #Detox #dietarysupplements
Illustration by the Folate Receptor Antibody Test