Baicalin-
Important Bioactive From Plants!
Baicalin is a flavonoid most famously present in the traditional Chinese medicine, Scutellaria baicalensis (Chinese Skullcap); however it is present in several other plants, including Blue Trumpet Vine (Thunbergia laurifolia), Indian Trumpet Tree (Oroxylum indicum), and Patchouli (Pogostemon cablin).
Among its possible health benefits:
· Antimicrobial
· Antiviral
· Neuroprotective
· Anticancer
· Anticonvulsant
· Antioxidant
· Hepatoprotective
· Neuroprotective
· Anxiety
· Eye Health
· Fertility
· Cardiovascular Health
· Joint Health
· Liver Health
In an interesting review of the antidepressant effects of baicalin and baicalein in experimental animal models, emphasis was made on the molecular mechanisms of their antidepressant effects including regulation of the HPA axis, inhibition of inflammation and oxidative stress, reduction of neuronal apoptosis and promotion of neurogenesis, as well as amelioration of mitochondrial dysfunction.
In a recent human clinical study involving baicalin, its safety was explored, along with tolerability, and pharmacokinetics in healthy Chinese subjects. This phase I randomized, double-blind, placebo-controlled trial assessed the effects of baicalin in single doses. The results demonstrated that baicalin was well-tolerated and safe at the tested doses. Additionally, the study highlighted that food intake significantly influenced baicalin’s pharmacokinetics, showing potential for optimizing its therapeutic use based on meal timing. This research is important for improving the bioavailability and clinical application of baicalin in various treatments.
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*This post is for educational purposes only. It is not intended to diagnose, cure or treat any disease. Always seek medical advice directly through consultation with a health professional.
Baicalin- Important Bioactive From Plants!
