Citral

Citral

Important Bioactive From Plants!

Citral  is an acyclic monoterpene aldehyde, pale-yellow in color with a strong  lemony odor. Citral occurs in essential oils of various plants,  including Lemon Myrtle, Lemongrass, Lemon Verbena, Lime, Lemon Balm,  Orange, Litsea cubeba, and Lemon Tea Tree. It is used commonly in  perfumery and for scenting products, but also confers health benefits.

Among its possible health benefits:
·     Antioxidant
·     Antimicrobial
·     Antifungal
·     Antiplanktonic
·     Antiinflammatory
·     Digestive Health
·     Microbiome Health
·     Pain Relief
·     Anti-Cancer
·     Anticonvulsant
·     Immunoresponsive
·     Mood-enhancing

Interestingly,  there has been much interest in the use of citral, or citral-containing  plants for use as antimicrobial therapies, especially having to do with  microbiome dysbiosis.

In  one recent preclinical study, Ginger essential oil and citral were  found to inhibit the formation of aortic atherosclerotic lesions,  improve plasma lipid profile, reduce blood sugar, improve insulin  resistance, decrease plasma trimethylamine-N-oxide (formed during  L-carnitine metabolism in the formation of plaques) and inhibit plasma  inflammatory cytokines. In addition, treatment improved the gut  microbiome through increasing diversity and beneficial microbes and  decreasing cardiovascular disease- related microbes.

A  study on the potential use of Citral in antifungal therapy against  Candida auris found Citral to have similar effects alone to antifungal  drugs in monotherapy (anidulafungin, amphotericin B and fluconazole).  Additionally, when combined with anidulafungin, it was found to have  synergistic and additive interactions, which may be helpful in clinical  development considering the thigh resistance levels to current  antifungals.

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*This  content is for informational and educational purposes only. It is not  intended to provide medical advice or to take the place of such advice  or treatment from a personal physician.

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