Important Bioactive From Plants!
Cyanidin-3-glucoside (C3G) is a naturally occurring anthocyanin with a glucose molecule attached at the 3-position of the C-ring. This glycosylation increases its stability and solubility in water, making it a prominent pigment in many deeply colored fruits and vegetables. C3G is responsible for the vivid red, purple, and blue hues in plants and is especially abundant in blackberries, black raspberries, blueberries, black rice, purple corn, and red cabbage.
Among its possible health benefits:
· Antioxidant
· Anti-inflammatory
· Neuroprotective
· Anti-diabetic
· Cardioprotective
· Anti-obesity
· Anti-cancer
· Visual Health Support
In a recent comprehensive review, the therapeutic potential of C3G was highlighted in combating obesity and related chronic diseases through its effects on lipid metabolism, energy expenditure, inflammation, and oxidative stress. C3G’s complex metabolic journey through the gastrointestinal tract and its bioactivity in regulating glucose homeostasis, cardiovascular health, and gut microbiota composition is detailed. The findings underscore C3G’s promise as a natural intervention for metabolic, inflammatory, neurodegenerative, and cancer-related conditions.
Another interesting study investigated the effects of C3G on gut-brain axis signaling in the context of obesity and cognitive decline. The researchers found that dietary supplementation with cyanidin-3-glucoside-rich purple corn extract in an obese animal model not only improved spatial memory and synaptic plasticity but also altered the gut microbiota composition, increasing the abundance of beneficial bacteria like Akkermansia muciniphila. These changes were linked to elevated levels of brain-derived neurotrophic factor (BDNF) in the hippocampus. The study highlighted how C3G may exert cognitive benefits indirectly through the modulation of gut microbes and systemic inflammation.
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*This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician.