In order to spread awareness about recent advances in medicinal plants & natural products science, this post series is intended to highlight some of the recently published research in the literature. Today’s highlight:
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation.
Zhang H, Ding X, Qiu Y, Xie M, Wang H, Li T, Bao H, Huang S, Xiong Y, Tang X. J Nat Med. 2024 Oct 22.. Online ahead of print.
Imperatorin is a naturally occurring furanocoumarin found in various plants, especially in species like Angelica and Peucedanum. It has a range of biological activities, including anti-inflammatory, antioxidant, and neuroprotective effects.
This research examines imperatorin’s protective effects against doxorubicin-induced cardiotoxicity, a common side effect of the chemotherapy drug doxorubicin.
Imperatorin was found to reduce cardiac damage by inhibiting the NLRP3 inflammasome pathway, which plays a role in inflammation and cell death.
Through this mechanism, imperatorin could potentially serve as a cardioprotective agent, reducing doxorubicin’s harmful effects on the heart without compromising its cancer-fighting properties.
Link to abstract: https://lnkd.in/gA6_3Wx6
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