Methylliberine is a naturally occurring purine alkaloid belonging to the methylurate class of compounds, structurally related to caffeine, theacrine, and other methylxanthines. Chemically, it is a close analog of caffeine but with subtle differences in methylation patterns. Methylliberine is primarily found in certain plants of the coffee and tea family (Rubiaceae and Theaceae), but most notably in Coffea liberica, Camellia assamica var. kucha, and Paullinia cupana (guarana). It is also present in Mitragyna speciosa (kratom) and in trace amounts in some other Amazonian or Southeast Asian botanical species.
Among its possible health benefits:
· Mild CNS Stimulation, non-habituating
· Energy
· Alertness
· Mood Enhancement
One interesting study investigated how caffeine, methylliberine, and theacrine affect reaction time, marksmanship, and cardiovascular responses in tactical personnel. Participants received either 300 mg caffeine (CAF), a combination of 150 mg caffeine + 100 mg methylliberine + 50 mg theacrine (CMT), or a placebo, and completed a 150-minute protocol including vigilance and marksmanship tasks. Both CAF and CMT significantly improved reaction time in vigilance tasks compared to placebo, with no effect on marksmanship. However, only the high-dose caffeine group showed a significant increase in diastolic blood pressure, while CMT maintained performance benefits without that adverse effect. This suggests CMT may offer a safer alternative to high-dose caffeine for maintaining alertness in high-performance settings.
#bioactives # #chemistry #energy #coffee #plantbased
Methylliberine-Important Bioactive From Plants!
