Important Bioactive From Plants!
Piperine is an alkaloid, and is considered the primary bioactive compound in black pepper (Piper nigrum) and long pepper (Piper longum), which are notable for their pungency and widespread use as spices in culinary traditions worldwide.
Among its possible health benefits:
· Bioavailability Enhancement
· Antioxidant
· Anti-inflammatory
· Anticancer
· Antimicrobial
· Neuroprotective
· Metabolic Benefits
· Analgesic
Interestingly, a preclinical study published in 2020 in the journal Phytotherapy Research investigated the potential of piperine as an antidepressant. The researchers aimed to evaluate piperine’s effects on chronic unpredictable mild stress (CUMS)-induced depression in animal models. The study revealed that piperine administration significantly alleviated depressive-like behaviors, and noted an increase in serotonin and dopamine levels in the brain, indicating an enhancement in neurotransmitter activity associated with mood regulation. Piperine exhibited neuroprotective properties by reducing oxidative stress and inflammation in the brain, contributing to its antidepressant effects.
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*This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician.