Pterostilbene is a naturally occurring stilbene compound, structurally similar and considered an analog to resveratrol, but with two methoxy groups replacing hydroxyl groups in its backbone. This subtle difference enhances its lipophilicity, metabolic stability, and bioavailability compared to resveratrol. Primarily found in blueberries and Pterocarpus marsupium (Indian Kino tree), with smaller amounts in other plants like grapes and almonds.
Among its possible health benefits:
· Antioxidant
· Anti-inflammatory
· Anti-cancer
· Neuroprotective
· Anti-diabetic
· Cardioprotective
· Immunomodulatory
· Anti-aging
· Autophagy promoting
One interesting study explored pterostilbene’s neuroprotective effects in Alzheimer’s disease models. Researchers demonstrated that pterostilbene significantly reduced amyloid-beta plaques, a hallmark of Alzheimer’s pathology, in transgenic mice. The compound enhanced autophagy (cellular cleanup mechanisms) in neuronal cells, helping to clear toxic protein aggregates. Additionally, treated mice showed marked improvements in memory and cognitive tasks.
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Pterostilbene-Important Bioactive From Plants!
